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& Pittas, A

- **ATC Classification**: Being classified under **A10BJ06** connects it directly to diabetes management, emphasizing its role in controlling blood glucose levels

Chiang Mai

While some peptides like semaglutide (a GLP-1 receptor agonist) have FDA approval for weight loss, others are available only through off-label use or experimental stages

In recent years, extensive research (Figure 2) has shown that TMAO can activate the inflammasome NOD-like receptor protein 3 (Nlrp3) through different pathways to activate the inflammatory signal pathway, resulting in aggravation of oxidative stress and, in turn, of endothelial dysfunction