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Acta 1773 , 12851298 (2007)

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Covert hepatic encephalopathy consists of minimal and grade 1 hepatic encephalopathy 1 , could impair the cognitive function, lower work efficiency, reduce the quality of life 6,7 , impair driving skills 8,9,10,11 , or results in poor prognosis 12,13,14

Moreover, NMN administration can significantly elevate NAD + biosynthesis in white adipose tissue, heart and the liver, but not the NAD + content in brown adipose tissue and kidney, suggesting a tissue- and cell-type-specific transportation of NMN to cells or tissues for NAD + biosynthesis presumably due to the deferent expression pattern of NRK1