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As depicted in Figure 2A, cholesterol stimulation significantly decreased, while EX-4 treatment increased the phosphorylation of AMPK and could reverse the effect of cholesterol stimulation in INS-1 cells, suggesting the involvement of AMPK signaling

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Ortiz C, Schierwagen R, Schaefer L, Klein S, Trepat X, Trebicka J

Their results show that the availability of extracellular GSH can alter sensitivity to different treatments, or even confer resistance to drugs that block the uptake of these amino acids, with the implications that entails

Notably, observed evolutionary distances within CAT clade 3 are comparatively shorter than within the non-metazoan clades 1 and 2 (Fig