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Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (Nos

10.1212/wnl.35.4.527 14 AuningE.SelnesP.GrambaiteR.altyt BenthJ.HaramA.Lvli StavA.et al (2015)

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While it is unknown which garlic bioactives can release H 2 S nonenzymatically, it has been hypothesized that the major bioactive S -allylcysteine found in aged garlic extract may also act as a substrate for the enzyme CSE to produce H 2 S.102 H 2 S deficiency and supplementation There is conflicting evidence about the potential age-related decline in vascular H 2 S production, but any impairments of H 2 S signaling may differ among tissues, with the liver being less susceptible to functional changes with age than less vital organs including the vasculature, which would be consistent with the triage theory of nutritional deficiencies.103,104 It is generally understood that most H 2 S gets oxidized within mitochondria to thiosulfate and further to sulfate