A complete response letter generally outlines the deficiencies in the submission and may require substantial additional testing or information in order for the FDA to reconsider the application
The 'first strike' mainly refers to insulin resistance (IR) caused by obesity and type 2 diabetes mellitus (T2DM) and hepatic steatosis caused by excessive accumulation of triglyceride (TG) and cholesterol in the liver parenchymal cells in the form of lipid droplets
By interacting with the GLP-1 and GIP peptides (those are our bodys natural responses to food), it can lower your hunger, slow your digestion, and create a path to healthy living
The milligram numbers are not comparable between the two molecules
Diabetes 51(6):19381948 Frustaci A, Chimenti C, Setoguchi M, Guerra S, Corsello S, Crea F, Leri A, Kajstura J, Anversa P, Maseri A (1999) Cell death in acromegalic cardiomyopathy