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After consideration of public comments we received, we are finalizing without modification our proposal to calculate the target PCR based on our longstanding target PCR calculation methodology described in this final rule with comment and then apply the 1.0 percentage point reduction as required by section 16002(b) of the 21st Century Cures Act

TB-500 does not bind copper or stimulate copper-dependent enzymes

Single-use syringes should be disposed of properly in sharps containers

Most patients describe it as a small pinch