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Q: What is rebound weight gain, and how can it be managed

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10.1016/j.biopha.2020.110669 Biomed Pharmacother

Although lifestyle interventions (low-calorie diets and exercise) are still the cornerstone of weight management, weight loss achieved through this approach is extremely difficult to sustain in the long term, particularly due to physiological adaptations that reduce the energy expended or increase appetite to compensate for the missing calories

This screening process is an important part of maintaining safety and treatment effectiveness