This slowing contributes to the appetite suppression that drives weight loss and the postprandial glucose-lowering effect, and it also drives most of the gastrointestinal side effect profile.[1],[2] A 2025 review in the Journal of Clinical Endocrinology & Metabolism summarizes the published evidence: GLP-1 receptor agonists impact gastric, intestinal, and gallbladder motility simultaneously, with effects on gastric fundus relaxation, antral contractility inhibition, increased pyloric tone, and reduced small intestinal motility.[3] The path from this mechanism to constipation is straightforward
Yet, the high stress and abundance of processed foods in the modern world make it challenging to maintain gut health, and sometimes we need some assistance
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The first of its kind initiative will uncover the biological mechanisms that determine individual variation in response to GLP-1s and find biomarkers associated with their safety, efficacy, and tolerability
Eur J Midwifery
