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In animal TLE models, HMGB1 acts through TLR-4 to increase production of cytokines such as IL-1, TNF, and IL-6 (Maroso et al., 2010)

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We looked at [alanine transaminase] and [aspartate aminotransferase] levels throughout the study, and similar to other GLP-1 receptor agonists, the levels were reduced throughout the study and stayed that way for 72 weeks, Alfaris said