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Specifically, the protocol provides that a dog classified as an "A" must be over 2.5 years of age and that SM is "absent or less than 2mm central canal dilatation in the C2-C4 region only"

0pubmed Yilmaz I, Akkuzu B, Cakmak O, Ozloglu LN

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The treatment of hormone-sensitive prostate cancer introduced by Charles Huggins is based upon androgen dependence of the tumor and includes bilateral orchiectomy and administration of estrogens, but is linked to adverse side effects 9