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For example, in both NCI-716 and STC-1 cells, berberine, a natural bitter plant alkaloid commonly used as an antibiotic, was shown to dose-dependently stimulate GLP-1 secretion via T2R38 ( 2 , protein kinase C and/or phosphodiesterase, attenuates GLP-1 secretion induced by bitter tastants (59)

A critical analysis of this evidence reveals a promising yet preliminary landscape

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