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Some weight regain can still occur, even when a person follows consistent nutrition and activity habits

In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)

Furthermore, since Mounjaro mimics GLP-1 hormone effects, it may influence bodily fluid balance and potentially impact tear production and evaporation

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If your plan excludes it, standard appeals won't work for a plan exclusion, but you have other options