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Use in Combination Therapy As dual therapy, GLP-1 receptor agonists are recommended in combination with metformin for patients who do not achieve A1C goals with metformin alone (36)

In pathophysiological states, including increased insulin resistance, the hybrid receptor number is changed significantly, thus potentially abrogating the chance for IGF-1 to alter glucose metabolism [129, 132, 133]

This observation laid the groundwork for the 68-week and 80-week TRIUMPH Phase 3 trials

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Tirzepatide, on the other hand, targets both GLP-1 and GIP receptors