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It is naturally found in every cell of the body and plays a key role in reducing oxidative stress, enhancing immunity, and assisting in the removal of toxins from the liver

They proposed that NOX2 and NOX4 play a crucial role in the development of IIM, possibly by depleting NADPH to generate excessive ROS, leading to oxidative damage to tissue cells and inducing ferroptosis

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In this review, we summarize several drugs and inhibitors that specifically target Gln metabolism

doi: 10.3389/fimmu.2018.01112 113