While small molecules like nicotine or estrogen can be absorbed via a patch, GLP-1 molecules are roughly ten times larger than the limit for skin absorption
This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46
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Researchers studying Retatrutide (GLP3-R) may also examine: For laboratory research use only
One more thing to consider is whether or not oral GLP-1 agonists obtain FDA approval for obesity