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As safety data in pregnancy are not available, women of childbearing potential should use effective contraception during treatment

Serious Warnings and Drug Interaction Considerations Serotonin syndrome represents the most clinically significant risk, occurring when methylene blue is combined with SSRIs, SNRIs, or MAOIs due to methylene blue's monoamine oxidase inhibition properties

In laboratory testing, tirzepatide binds to the GIP receptor with affinity comparable to native GIP itself, but its GLP-1 receptor affinity is roughly five times lower than native GLP-1

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