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That represents a safety margin of approximately 3,750 times

Chapter 5: factors influencing skin aging and the role of estrogen

Holmgren A, slund F (1995) Glutaredoxin

It is one of the most pleiotropic hormones in human biology, regulating a wide range of physiological processes, including cell growth and proliferation, protein synthesis, carbohydrate and lipid metabolism, and body composition

Oxidative stress is a key driver of uneven pigmentation, triggering excess melanin production in localised areas