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Free radicals are molecules that are potentially toxic to cells

Its pathogenesis is related to genetics, oxidative stress, lipid metabolism disorders, hemodynamic abnormalities, inflammatory responses, cell apoptosis, and renal fibrosis (Flemming et al., 2018)

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It is therefore often seen in women aged 20 to 70 (the population most often affected with constipation), but its development does not depend on age or duration of constipation