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(2014) 6:263ra158

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These include myocardial I/R injury, diabetic cardiomyopathy (DCM), sepsis-induced cardiac injury, hypertrophic cardiomyopathy, atherosclerotic cardiovascular disease, HF, aortic aneurysm (AA), and hypertension (Figure 7)

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In these models, homozygous mutation of either Prop1 or Pit1 genes cause an abnormal development of the anterior pituitary, which in turn leads to decline in production of GH, thyrotropin (TSH), and prolactin (PRL), with consequent decrease in circulating IGF-I and thyroxine levels (Bartke, 2011)