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Annu Rev Nutr (2016) 36:33767

Clinical studies have revealed that tirzepatide injections can help participants lose between 15 to 20 percent of their body weight over 72 weeks

[10] [11] The lack of IGF-1 (or inhibition of IGF-1R) causes impaired cellular morphogenesis to occur, which prevents lipids from being secreted in some keratinocytes that build out the lamellar bilayer of the skin at the SC-SG interface around the follicles

Consider holding your next dose and contacting your prescriber if you experience severe or persistent gastrointestinal symptoms

doi: 10.1038/s41416-019-0717-x 47 WangJYeCChenCXiongHXieBZhouJet al