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Some people cannot tolerate the medication, have health conditions that make it unsuitable, or need a different approach

Such color changes are often attributed to the deposition, production, or increased accumulation of various endogenous or exogenous pigmented substances

The commercial potential is propelling drugmakers like Novo and Lilly to the top of the US and European markets

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Clinical Indicators for Switching: Response, Tolerance, and Efficacy Profiles Healthcare providers consider several factors when evaluating whether a switch is appropriate: inadequate weight loss response at maximum tolerated dose, gastrointestinal side effects that limit dose escalation, or a need for enhanced metabolic impact