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Heres why use of SGLT2 inhibitors causes an increased risk of this adverse event: The stress of surgery, change in dietary intake, and possible reduction in insulin dose around the time of surgery already disrupts blood sugar regulation

Accordingly, a recent study demonstrated the stochastic S-palmitoylation of engineered Cys residues in membrane proteins, proposing that catalysis is determined by substrate accessibility and not specific sequences 52

It is essential for healthcare providers to consider factors such as patient tolerance, treatment goals, and the specific metabolic responses observed during therapy

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