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2025 Apr 2:102053

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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

This is the foundational reason these peptides are dosed multiple times daily in most research protocols, typically 23 times per day at intervals of 812 hours