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Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

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This uptake depends on a protein called intrinsic factor (IF), which captures B12 in the small intestine, absorbing it in the final stretch of your small intestine (the ileum)

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