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This insight can then guide the development of multifaceted strategies targeting immune organs, cells, and signaling pathways to restore immune competence, eliminate SnCs, and delay age-related dysfunction

The European Medicines Agency (EMA) and MHRA continue to monitor adverse event reports, but anxiety has not been identified as a recognised side effect requiring specific labelling or warnings

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In the medulla, an elevated UA concentration results in the deposition of urate precipitates and the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome