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Consistent with these findings, left ventricular mass and heart weight were lower in hypertensive semaglutide-treated Glp1r VSM+/+ mice but not in Glp1r VSM/ mice (Supplemental Figure 3, D and E)

Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production

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In 2017, the Food and Drug Administration (FDA) approved Ozempic, which contains semaglutide as the main active ingredient, as a treatment for type 2 diabetes

Desnutrin/ATGL activates PPAR to promote mitochondrial function for insulin secretion in islet cells