Globally, B12 deficiency affects a significant portion of the population, ranging from 6% in some groups to as high as 20% in older adults
Crucially, several of these effects appear independent of weight loss, strengthening the argument that GLP-1s promote direct neurobiological benefits for brain health and dementia prevention
It is possible that glutamine, by increasing GLP-1 levels, which mediate FM and body weight reduction or replace FM with muscle, improves body composition in diabetes mellitus [28]
When researchers gave carriers a glucose challenge and measured blood markers every five minutes for four hours, the PAM variant carriers showed elevated GLP-1 levels but no corresponding increase in biological activity
The results of our current HIV study together with our previously published aging studies suggests that glutathione deficiency could play an important role not only in normal aging but could also be contributing to accelerated pathological aging, like HIV infection, said Sekhar