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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

(Skip ahead to read about the safety limits of stretching your pen supply.) Minimizing Side Effects and Improving Tolerance Gastrointestinal disturbances are the most common side effects of GLP-1 medications, affecting approximately 50% to 60% of patients during the initial treatment phase

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It activates GLP-1 receptors to lower blood sugar levels, slow how fast food moves through the digestive system, and curb appetite