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Its long-term safety profile, optimal dosing, and broader clinical utility remain under investigation in ongoing Phase 3 trials

Post-discontinuation, 19.6 % restarted the original medication, while 35 % adopted another option: alternative medication (27.4 %), healthcare visit for lifestyle modification (13.7 %), and metabolic and bariatric surgery (0.6 %)

Despite lots of big lingering questions, many clinicians dont think it actually matters right now how GLP-1 interacts with brain receptors on a cellular level, says Laura Huckins, PhD, an associate professor of psychiatry at the Yale School of Medicine

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