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Results Key proteomic differences between children discordant for konzo in pilot study To determine if protein levels differed between children affected with konzo and unrelated/unaffected individuals, we carried out liquid chromatography-tandem mass spectrometry analyses (LC-MS/MS) of plasma samples collected from 60 individuals (31 affected, 29 unaffected) from the Kahemba region of the DRC in 2011 (Discovery Cohort)

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Reduced levels of glutathione inhibit the detoxification process and disrupt skin cell turnover, resulting in slower regeneration and repair