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Short-chain fatty acids (SCFAs) SCFAs are among the most extensively studied metabolites in host-microbiota interactions

Risk is higher with certain diets or meds affecting absorption

Arch Iran Med 22(4):204210 Scioli MG, DAmico F, Guzmn RR, Miranda EM, Orlandi A (2019) Oxidative stress-induced endothelial dysfunction contributes to cardiovascular disease

Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches

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