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Contraindications XIGDUO XR is contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m2) or end-stage renal disease [see Warnings and Precautions (5.1)]

If the label says "5mg lyophilized retatrutide," your vial contains 5 milligrams of peptide in powder form

Reconstitute under sterile conditions using bacteriostatic water or approved diluents

Resolution rates In published cases, every patient who discontinued the medication experienced complete resolution of allodynia symptoms

Female sex While the trial data does not provide a definitive gender breakdown for skin sensitivity specifically, studies on allodynia and dysesthesia across the GLP-1 class suggest women may be slightly more susceptible than men