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Most reproductive endocrinologists and maternal-fetal medicine specialists recommend stopping tirzepatide at least one menstrual cycle before attempting conception, though some suggest three months to allow full washout and restore baseline metabolic function

9 , e1003731 (2013)

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There is also emerging research suggesting that GLP-1 receptor agonists may influence brown adipose tissue activity and energy expenditure, though this mechanism remains speculative for tirzepatide and its clinical significance in causing cold sensitivity is not established

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