The liver benefits appear to result largely from weight reduction and improved metabolic health rather than direct liver-specific effects, which is why NICE recommends lifestyle modification as first-line treatment for fatty liver disease
Keywords: semaglutide, GLP-1, once weekly, type 2 diabetes, ethinylestradiol, levonorgestrel Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that potentiates insulin secretion, inhibits glucagon secretion, reduces appetite, and delays the rate of gastric emptying in response to food intake
Recommended monitoring protocol: Baseline: Full thyroid panel (TSH, free T4, free T3, TPO antibodies, thyroglobulin antibodies) plus thyroid ultrasound before starting GLP-1 therapy 6-8 weeks after starting GLP-1: Recheck TSH and free T4
These are the operational targets we design for
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