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Andrews and colleagues (2009) demonstrated that MPTP-induced dopaminergic dysfunction is amplified in GHSR KO animals, and selective re-expression of GHSR1a in catecholaminergic neurons of GHSR KO animals reduced this degeneration

The extended-release (ER) formulation encapsulates exenatide within biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres, which form a polymeric matrix that allows sustained drug release following SC administration [13, 14, 58]

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Once a consistent time is set, steady timing helps maintain the flat profile and simplifies interpretation of fasting readings