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[1] [2] Tirzepatide (Mounjaro for diabetes, Zepbound for weight management) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, not a pure GLP-1 agonist
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It demands a nuanced, unflinching look at the mechanisms, the potential rewards, and, most importantly, the profound unknowns
They were also unable to determine whether CVD reductions were due to semaglutide treatment or from other risk factor interventions
Upregulation of VCAM1 is also reported in BECs activated by C3a/C3aR signaling, causing vascular dysfunction and age-associated neurodegeneration (Propson et al., 2021)
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