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Dihexa can often be safely combined with other cognitive enhancement therapies including omega-3 fatty acids, B-vitamins, nootropic supplements like Lions Mane or Bacopa monnieri, acetylcholine precursors, and brain-supporting nutrients when properly coordinated under medical supervision

This distinction has important implications for therapeutic timing: anti-inflammatory interventions may be most effective if initiated early post-insult to prevent the establishment of chronic tinnitus, but may also confer benefit in established tinnitus by reducing sustained inflammatory signaling that perpetuates maladaptive plasticity