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They can improve weight, insulin resistance, and menstrual regularity in selected patients, especially when combined with lifestyle modification or metformin

GeneReviews [Internet]

Main pathway: G-actin sequestration Native T4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 M, controlling the pool of free actin available for polymerization into F-actin (actin filaments)

This mechanism was validated by dapagliflozin (hypoglycemic agents) and atorvastatin (hypolipidemic agents) treatment in diabetic mice kidney and PA/high glucose-induced podocytes [69, 70]

- Cellular health maintenance: protects mitochondria and promotes tissue regeneration