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PMID: 16635664 Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Refsum H et al

Metformin (for diabetes), proton pump inhibitors (such as omeprazole or esomeprazole), and H2 blockers (such as famotidine) can all reduce B12 absorption over time

The Centers for Disease Control and Prevention (CDC) states that if a multi-dose vial has been opened or accessed (e.g., needle-punctured) the vial should be dated and discarded within 28 days unless the manufacturer specifies a different (shorter or longer) date for that opened vial

Yes, you can give yourself vitamin B12 injections if youre trained and know how

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