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A common motif found in most lipids is a long-chain acyl group, often referred to as the hydrophobic tail, usually in the form of fatty acyl esters (but also amides in sphingolipids and alkyl or vinyl ethers in ether phospholipids)
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For GLP-1 medications like semaglutide and tirzepatide, cost is often the biggest barrier to starting treatment, or staying on it long enough to see results
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