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thus, GSH depletion ultimately leads to increased lipid peroxidation 23

The participant must be at least 18 years old and: Have a BMI of 35 or greater, or Have a BMI of 30 or greater with a diagnosis of diastolic heart failure, uncontrolled hypertension or chronic kidney disease Stage 3a or higher, or Have a BMI of 27 or greater with pre-diabetes, previous myocardial infarction or stroke, or symptomatic peripheral artery disease