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[13] [15] Rare but serious side effects include hypersensitivity reactions, such as urticaria, angioedema, or anaphylaxis, which require immediate medical attention

However, if you have a "Slow COMT" mutation or a highly sensitive nervous system (common in MCAS and dysautonomia), taking methylated B12 can be disastrous

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They are commonly used within provider-guided wellness protocols designed to support balanced eating habits, routine consistency, and overall metabolic function

For this reason, its been used to help enhance athletic performance, fight fatigue, and provide additional energy to get through hectic schedules