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Hypersensitivity Reactions Severe, life-threatening, generalized allergy, including anaphylaxis, generalized skin reactions, angioedema, bronchospasm, hypotension, and shock have occurred with insulin, including TRESIBA and may be life threatening

Lyzenga-Dean, "One study reported that 50% of patients taking GLP-1 agonists experienced nausea while taking them." The Rebound Effect Discontinuing GLP-1 medications often leads to weight regain

10.1016/s0952-7915(99)00052-7 27 Britannica (2020)

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However, GLP-1s also offer well-established research with fewer gastrointestinal side effects