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S100 plays a role in dealing with oxidative stress hence this increase is perhaps indicative of increased oxidative stress (Hu and Lin, 2021)

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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]