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In a meta-analysis of 40 studies, people with the 677 TT genotype had a strikingly similar 16% higher odds of coronary heart disease compared with those with the CC genotype: These results support the hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD

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Cytochrome P450-mediated alterations in clinical pharmacokinetic parameters of conventional drugs coadministered with piperine: a systematic review and meta-analysis