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Medicines made from this hormone, known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs), were originally designed to help those with type 2 diabetes to manage their blood glucose levels 2

Similarly, both gut-selective and systemically active doses of sitagliptin increased plasma levels of active GLP-1 and reduced TG excursion after olive oil gavage in Dpp4 Gut/ mice (Figure 4, C and D)

One subject randomized to liraglutide 1.2 mg had antibodies that crossreacted to GLP-1 in vitro at the end of the trial (the subject was exposed to both liraglutide 2.4 and 3.0 mg during the extension period)

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