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Specifically, the binding of IGFBP3 to GRP78 increases autophagic site formation and autophagic system flux, thereby promoting breast cancer cell survival even under glucose starvation and hypoxic conditions (57)
Therefore, considerable attention is also being paid to synthetic antioxidants, which can be designed or modified to exert more favorable pharmacological and safety effects than their natural counterparts (see Table 2)
Tung JY, Boodhansingh K, Stanley CA, et al
Thus, the combination of semaglutide and SGLT2is offers a multifaceted approach to optimise treatment outcomes for patients with CKD and T2D, underscoring the need for further research to establish definitive guidelines for their combined use in clinical practice
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