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Further subgroup analysis revealed significantly higher pS- -Syn levels in patients with late-onset PD than those with early-onset disease, as well as in patients with postural instability and gait difficulties than those with tremor-predominant PD, but obviously lower in patients with cognitive deficits and olfactory loss with PD (Li X

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Biologic therapies are better suited for advanced degeneration, chronic pain from structural issues, long-term joint deterioration, and significant tendon or ligament injury