Opportunities for integration of PDX models into clinical trials
While direct evidence for NGFs efficacy in tinnitus patients remains to be established, its established role in neuronal survival, synaptic plasticity, and emotional regulation, combined with emerging bioinformatic evidence of its involvement in tinnitus-related synaptic processes, provides a compelling rationale for further investigating the hypothesis that targeting the NGF/TrkA pathway could simultaneously ameliorate auditory perceptive distortions and the debilitating emotional symptoms that often accompany chronic tinnitus (Gross et al., 2023
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Glutathione is a powerful antioxidant that helps to protect the body from free radicals and other harmful substances
This makes the combination particularly interesting for tendon and ligament regeneration studies