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The end products of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), are highly reactive and can form adducts with proteins and DNA, impairing their function [33]

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Similar to previous peptide-bound:GLP-1R:G s complex structures, the highest resolution was observed within the G protein and receptor TMD, with lower resolution in the extracellular half of the receptors, including the ECD (Supplemental Figure 1), indicative of greater flexibility in these regions

Similarly, Otulak-Kozie et al